Background: Psychological wellbeing (PWB) is linked to reduced cardiometabolic disease (CMD) risk. Although most studies measure PWB once, trajectories of PWB over time might relate differently to future CMD risk. Hypotheses/Research questions: We tested if trajectories of 4 PWB facets would be associated with lower incident CMD risk. Sample characteristics/Sample size: Data are from the English Longitudinal Study of Ageing. Participants were 4,006 adults aged ≥50 years followed across 17 years and assessed at 2-year intervals, without history of CMD at wave 1 baseline and who remained CMD-free up to wave 5. Design: PWB was measured 5 times from waves 1-5 using the Control, Autonomy, Satisfaction, and Pleasure scale (CASP). Trajectories of control, autonomy, self-realization, and pleasure were defined using latent class growth modeling. CMD cases were assessed at each follow-up (waves 6-9) over 9 years. Cox regression models estimated likelihood of incident CMD associated with trajectories in each CASP subscale separately and cumulatively (i.e., having persistently high PWB levels on 0, 1, 2, or 3-4 subscales). Results: For each subscale, 3 or 4 trajectories of PWB were observed. 441 incident CMD cases occurred. In demographics-adjusted models, CMD risk was reduced by 34-51% for adults with persistently high vs. persistently low levels on each subscale (e.g., autonomy: Hazard Ratio (HR)=0.66, 95% Confidence Interval (CI): 0.50-0.89). After adjusting for health factors and depression, CMD risk remained significantly lower for pleasure and self-realization only. Adults with persistently high levels on ≥2 subscales vs. none had 44-49% lower risk of CMD (e.g., persistently high on 3-4 subscales: fully adjusted HR=0.56, 95% CI: 0.38-0.82). Scientific contribution: Sustained pleasure and self-realization and experiencing persistently high levels of >2 PWB facets were associated with reduced CMD risk. Effect sizes for trajectories were generally larger than those previously obtained with a single PWB assessment.